Absolutely, there is a big difference in feel and operation between each type of camera. They both are capable of producing high quality images, they just go about it differently. Better, worse, that's up to the individual to decide. If one were to go cold turkey from DSLRs to mirrorless it could be a shock. It didn't happen seamlessly for me but instead I adapted over time. Once I became happy with using the viewscreen I tried different ways of holding the camera, to the point where my most common grip is now using a "thumb trigger" on the shutter button.
I still love the shutter/mirror sound on my 50D, it fits my hand well and I can operate the controls without looking which I still can't quite say the same for any mirrorless camera. I just decided that I had to make a choice one way or the other and I realised that choosing to stay exclusively with my DSLR gear would have been a result of familiarity, not functionality. Simple as that.