IMO, you can always visit Yosemite Valley, but the high country (Tuolumne/Tioga Pass) is were it "is". Since the high country was recently open for the season, make sure you take a day (or two) there.
FWIW, there's a new webcam: Yosemite Falls Webcam
I don't have the 10-22mm, the widest that I have is the 17-40. I would say most of my Yosemite shots were taken with my 70-200 f/4L.