Here's what I would do.
Camera on a tripod (duh) and either a wireless remote trigger or a helper.
I'd shoot at 4.0 or 5.6 max in order to help keep the ISO low and flash power not at max. If you want everything sharp front to back, you'll have to dial up the f/stop to f/11 or f/16. For me, I like the background a little blurry and car super sharp.
Once you decide on your f-stop, figure out your ISO - if you have a good camera with low noise you should be able to go to 800 if necessary. I prefer to keep it under 800 as much as possible. I'd set ISO as low as you can get it without having multi-second exposures unless that is a look you want. Nothing wrong with multiple second exposures it just adds to the time for each shot and increases the chance for motion blur to creep in (wind, a bump on the tripod, etc).
Expose for the background so you don't have pitch blackness or blown out lights from buildings (no strobes - just get the background right. Strobes won't be lighting up the background anyway). You'll leave your aperture set and adjust shutter speed and ISO to get your exposure.
Now add your strobe. Just start at say 1/2 power on your strobe and take a test shot. I'd recommend having your light up as high as practical (7-9 feet) and angled down at the ground so it is NOT pointed right at the car. You can experiment with angle and distance to get the look you want.
Dial in your power. If you hit max power and the exposure is still dark, you'll need to give something up - raise your ISO, or open your aperture.
It's a meticulous process - there is no ONE super setting that is perfect. The answer is it all depends - on your camera, strength of your strobe, if you have a helper, if you are in the middle of nowhere or in a brightly lit parking lot, if you are shooting at the blue hour (which I recommend - it's beautiful) or hours past sunset.
Hopefully this gets you started!