I totally agre with Sheldons post above, first impressions can be quite daunting at first, I imagine most people that buy that body may wel have used canon bodies before, that will certainly be useful, and speed up the learning curve.
I actually think the layout is great, but would only say that after several thousand shots.
there are so many ways to set up the 1D2 to suit your own needs, (simple things like having the ISO display in the viewfinder etc. ) saves looking on top display.
I thought Redbut made a good point about the need to use two hands to adjust some settings (buttons / dials) big advantage in my view. or setup moved by acident to easilly.
One thing to take care with . if the rear wheel is turned on, say using for adjusting exposure compensation settings + or - ...always check the wheel has not been knocked/moved. a bit late after if you find shots have been done at + 2 stops over !
Once you arrive at the stage of thinking this is all a piece of cake and you know that body inside out, try it all over again but this time set up and use it in the dark, sure we can illuminate the display, but just try it for fun, you may learn something.
just get out there and shoot and enjoy using one of the worlds top cameras.
Cheers
Martin (Huckaback Photo)
Old photographers never die. They just go out of focus