After getting my hands on a F-Stop Tilopa with the large ICU, I have to say for hiking it is my favorite. For moving all of your gear, the Kiboko is perfect. I can fit all of my gear in the pack and a tripod on the outside. Carrying it in the boot of my car or in an overhead bin on a plane (just don't let an airline employee lift it) is what it was designed for, taking more than half of the gear for a 4 mile hike is going to wear on you. At 5' 10" I felt the Kiboko rode low on my back. While the shoulder straps and waist belt are ingenius for storing away, for hiking I never felt I could get the waist belt to take the bulk of the load. But like I said, it will carry everything I have in my signature plus average accessories. At $400 it is reasonably priced for the materials and the number produced, but very expensive for giving me one place to store all of my gear in a closet.
Since I am more interested in either urban photography, getting out on the trail and sports photography I thought I'd try the F-Stop Tilopa. After reading reviews and posts I thought it would be more useful since it is designed as a backpack first with the ICU added afterwards. I chose a TIlopa, for the padded laptop sleeve and a slightly larger bag, over the Loka. With a large ICU I can carry my 5D MkII with grip and RRS l plate with the 70-200 2.8 attached, 1.4x II extender, 17-40mm, 24-70mm and the 50mm 1.4 (all without hoods which ride above the ICU in the pack). Having the space for a rain shell, hat, a couple of snacks, 2 liters of water and a tripod as needed. With this gear the bag was confortable over a 5 mile hike. One issue I found was that with the 5D on the bottom of the ICU, with the grip an L plate I could feel the top of the body in my lower back. Changing out the dividers so that the 5D rides near the top it was not as noticable. I'm planning on replacing the ICU with one of the new pro ICUs in the same size as well as get a medium pro ICU. In order to carry all of the gear I can fit in the Kiboko I would need to get one of the XL ICUs, but then that would take almost all of the space in the bag. The only debate is whether I go for the Tilopa BC when I upgrade the ICUs as well for the beefier waist belt, which I think would be nice, or possibly the Loka or Guru for around town. Since I've only seen some of the smaller Clik packs, and was unimpressed I will say at this time the Tilopa is the best choice for an all around backpack.