Actual pictures from a real Canon 60D and a Sigma 150-500mm optical stabilizer lens.
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Focal Length: 247.0mm
Aperture: f/29.0
Exposure Time: 0.033 s (1/30)
ISO equiv: 100
Exposure Bias: none
Metering Mode: Matrix
Exposure: shutter priority (semi-auto)
White Balance: Auto
Flash Fired: No (enforced)
Orientation: Normal
Color Space: sRGB
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Focal Length: 213.0mm
Aperture: f/5.6
Exposure Time: 0.0013 s (1/800)
ISO equiv: 125
Exposure Bias: none
Metering Mode: Matrix
Exposure: shutter priority (semi-auto)
White Balance: Auto
Flash Fired: No (enforced)
Orientation: Normal
Color Space: sRGB
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Focal Length: 500.0mm
Aperture: f/10.0
Exposure Time: 0.0063 s (1/160)
ISO equiv: 100
Exposure Bias: none
Metering Mode: Matrix
Exposure: shutter priority (semi-auto)
White Balance: Auto
Flash Fired: No (enforced)
Orientation: Normal
Color Space: sRGB
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Focal Length: 500.0mm
Aperture: f/10.0
Exposure Time: 0.0016 s (1/640)
ISO equiv: 800
Exposure Bias: none
Metering Mode: Matrix
Exposure: program (Auto)
White Balance: Auto
Flash Fired: No (enforced)
Orientation: Normal
Color Space: sRGB
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Focal Length: 500.0mm
Aperture: f/10.0
Exposure Time: 0.0013 s (1/800)
ISO equiv: 3200
Exposure Bias: none
Metering Mode: Matrix
Exposure: program (Auto)
White Balance: Auto
Flash Fired: No (enforced)
Orientation: Normal
Color Space: sRGB
This may give a hint of how the combination works.