Back in the day of the 20D/30D a lot of people considered its 6.4 micron sensel to be the ideal size. The technology and the market have moved on, but I am still enamored of the 6.4 micron sensel, which is exactly what the 5D2 has. It is certainly worth noting that with the 1DX Canon has gone to a 6.9 micron sensel.
The 38 MP FF sensor will have the same sensel size and density as a 15 MP 1.6 cropper. There seem to be plenty of satisfied consumers for this level of sensor resolution and even higher. My 5D2 has a native print size of 10.4x15.6 inches at 360 ppi for my Epson and I print mostly at 11x16.5, so the uprez is not great and very little IQ is lost. The Nikon will be native for Epson at 14x21 and that would mean a downrez, so I doubt I would see much difference. The occasional 20x30 or larger would be better under close examination, but, again, I doubt the gain would be great at normal viewing distance.
Those 217 MB 16 bit tifs will for sure have more people finishing up in LR/ACR and avoiding the extra touch in PS.