I went to istanbul last year and my advice is:
1. reduce the things you bring, like the tele and tripod
2. wide angle is used much more on vacation
I don't know. It really depends on what kind of thing you shoot. Detail shots are done well with telephoto. Establishing shots done best with wide.
When I was in Turkey a couple months ago I really split my time up between the 85mm 1.2 70-200 and 16-35. Almost all my close up work was done with the 85 and 70-200 and an extention tube. Both lenses are crazy big n heavy, but I wont leave the house without em.