How difficult or easy the flashes are to use always depends on how you use them. And let's face it, none of these is as easy to adjust as a studio strobe!
When the flash is on the camera, they are all pretty easy to control because the camera menus can do most of the work, and the buttons on the flash do the rest.
Off-camera with a the ST-E2 in ETTL, they are still pretty easy. The older I versions have a simple slider to enable Slave control, and that is nice compared to the newer ones. But not a huge thing.
In manual mode on Radio triggers, I find the 430 flashes to be a pain in the ass. Much easier to adjust the power on the 580.
Anyway, I going to replace the whole mess of stuff with the new 600 setup soon anyway!