I used the 622's for an event this weekend, and the triggering and operation was largely reliable.
I had one issue where I had accidentally touched the channel button and switched receiver channels, causing no firing which took a couple of minutes to figure out. D'oh!
The only point I had a few problems was where the remote flash was about forty feet away with a fairly large crowd of people in between it and me. There were a few issues with triggering - I'd see the flash go off but the exposure wouldn't have much flash component. I wondered if I was getting those timing errors I'd experienced this week in testing. I can't say that this was down to unreliable triggering, as there may well have been other issues going on (people in front of the flash, flash recycling etc) and I was also getting missed shots most likely due to flash recycling issues. But it did give me some undesired behaviour to work around.
The weirdest one that happened a few times was that I'd be getting the exposures I wanted, then the flash would get really bright (like a full dump) for one shot and then die, not firing again at all until I faffed around with FEC down to a minimum and brought it back to life, upon which it would go back to firing normally as expected. Again, not sure what's going on here, it's difficult to troubleshoot those things during an event situation, and as it's the first time using remote ETTL flash at an event, I was expecting some oddness. I did switch to manual after some of these quirks which seemed to help a bit.
All in the process of understanding the behaviour and performance of the system so I know what to expect going forward...