I've been on the hunt for a bag for "small kit outings". Something to carry my 5D II plus a couple of lenses. I tried the Domke F-5XC and the F-3X but neither was really "right". The F-3X didn't have enough dividers of the right size and was tough to shoot out of. The F-5 was too stiff and too small.
I almost gave up on Domke but decided to give the F-6 a try.
Here you can see it with just the 70-200 in it (for size) and another shot of the bag with my 5D II and 24-105. Notice how the camera is wider than the bag bottom, yet it fits fine. That's the beauty of Domke.
The bag is tall enough for the body plus lens and could hold a longer lens (mounted) but not as long as the 70-200.