Rule 1 is to use proper technique.
I'm not the youngest around (52) but this week I went on a "happy-photography-moment" with a full-manual setting. No AF, No IS!
It was a sunny day and had on my back a 600d + 500mm reflex-lens (handhold).
The book discribes 1/1000 to be the lowest shooting speed but at times I only came at about 1/125 and still produced acceptable results.
This combo was not ment for high-quality shooting but hell it was big fun. Most of the objects were moving and keepers rate went about 2/3.
When handhold-technique are inefficient one can use techniscal aids as we can find in the video department.
Good luck (and fun),