I use a 5D and a 60D, basically interchangeably. I have better glass for the 60D: 10-22, 15-85. But the 5D is quite capable even with mediocre glass. I use the 20-35 and 28-135 on it and am happy with the results. OK, the 20-35 distorts worse than any other lens I've ever used, but I live with it, thanks to Lightroom. I use my longer zooms, 70-200 & 100-400, on both bodies. I get more reach with the 60D, and more modern controls and options. But I like the files out of the 5D better.
I kind of chuckle at folks who claim the 60D is a too small or that the 5D series is just too big. I have grips on both of them. Neither is too large too handle. I don't even notice the difference in size anymore. Sometimes I have to look at the body to see which one I am using.
Dedicated APS-c shooter. Gripped 60D, 60 2.8, 10-22, 15-85, Σ70-200 OS and a big white something or other! Plus a 5D w/28-75.