I initially used FoCal with my 5D mark iii. I liked the ease of using it and other than the necessity to make some of FoCals' adjustments manually for the camera, the results it gave were an improvement over not microfocusing...that was with 5 Ls and an 85 f1.8.
But, as most of my photography is done from the 50-100 feet to subject range, the 30' or so I used with Focal, I reasoned I needed to redo it at perhaps 75 feet. Realizing that Focal would likely have a hard time at, say, the 24mm end of my 24-105, I opted for Lens Align Pro and set it up outdoors. The results were, on average, plus/minus 1 or 2 from what I got with FoCal. I'm now a completely happy camper with the absolutely dead-on, incredibly sharp focused results I'm now getting. As an amateur, I'll probably repeat the process next summer, just in case something needs a small tweak or two.
edit: forgot to mention...when I had my 60D, my 24-105 seemed a tad soft, and the 85 f1.8 was less than ideal as well. After FoCal and then Lens Align...perfect!