I have a few bags and a belt system. There are times when I strip out all the lens holding padding and just drop the loaded belt system in the bag. My belt and some of the pouches are think tank, other pouches are tamarac. ThinkTank also makes camera holsters that will take gripped bodies with a lens on them.
I also have a ThinkTank Airport Security that I take to sporting events and lock the bag to a table (usually find one that's built into a wall) or support beam.
One body, two lenses and a speedlight? Look at messenger bags, I love my ThinkTank retrospective, but there are many options, including Domke and there's a thread somewhere about a $20 messenger bag from amazon that's for like school books, then spend another $20 on a camera padding insert and it works just as well but, won't scream camera bag.
Where in Indiana are you? I may be able to recommend a place to check a few bags out.