Those of you who know me, know that I prefer to shoot single frames at F11 or higher. One way to deal with diffraction is to carefully sharpen an image. No, I won't recover detail that's lost to diffraction -the computer will never be able to recover data that I didn't record with the camera. But you can decrease the level of "perceived diffraction softening". The trick is to sharpen an image without introducing a lot of noticeable artifacts.
A few days ago I bought a license for Topaz Labs Sharpen AI (used my own money, so this isn't an add in disguise). Here's a shot taken at 5x and F11 processed with Topaz Labs Denoise AI, Sharpen AI, and Clarity (contrast adjustments). I'll let you decide if it looks good for a single frame.
Tech Specs: Canon 80D (F11, 1/250, ISO 100) + a Canon MP-E 65mm macro lens (5x) + a diffused MT-26EX-RT with a Kaiser adjustable flash shoe on the "A" head (the key), E-TTL metering, -1/3 FEC, second curtain sync. This is a single, uncropped, frame taken hand held.
Link to full size image
Unsharpened version for comparison:









