No, the 70-200 did not get in the way of closing the bag. What I liked about that setup is that I could fit all my stuff in it AND have easy access to it without taking the bag off. I have since sold that bag and bought the 300 because I bought the 40D which didn't quite fit very well. The 300 is bigger, but I can't seem to arrange it the same way. The sizes of the inserts combined with the different dimensions of the bag made it impossible. So now I am thinking about getting the 100 when I only want to carry a few things.