Here's a sample from a 5D. Image made hand-held, 1/15 at f/5.6 (wide open at 12mm). The corners do go soft, but I don't think it undermines the image. The first image is the full frame, with miminal PP including sharpening. The second is a couple of 100% crops, one from the center and the other from the corner, with no sharpening.
The soft corners don't bother me at all, but the flare from the sliver of visible sky does a bit. This is one of the few images I've made where the flare was noticeable (and, no, I'm not talking about ghost reflections).
Given the settings and subject, this probably represents the worst-case performance with this lens. I can certainly live with it.
Unlike with my 10D, this isn't a walkaround lens on the 5D--it's too wide for that. But when you need it, nothing else will do, and the image quality is good enough such that you don't have to reserve it for the occasional novelty shots.
Rick "working through some recent material" Denney