Obviously there is going to be a period of adjustment. I, for one, have the same "problem" with anything except the 1's.
The main difference is in the layout of the controls on top of the body. Instead of the knob, shooting mode is selected by pressing the mode button (left hand) and turning the main dial (right hand).
The controls you find over the top LCD on the 5D/7D is on the left side on the 1's. They work in the same way as changing modes. press 1 or two buttons with your left hand and turn the dial with your right hand.
To me this is a much smoother and more natural way of doing it, but others may feel different.
To be honest, the mode-changing-knob annoys me. I change settings many times more than I change shooting modes, so having a dial that only changes mode, taking up the entire left side of the camera (thereby effectively rendering my left hand useless) doesn't make a lot of sense to me.
Again, this is just my opinion. Others may disagree. No one is right or wrong here. At the end of the day, what matters is that YOUR tools feel right in YOUR hands.
Would you be lost? I have no idea. I have talked to people who never got used to it, but most people I know / have talked to, who made that change, would never go back.