The first item listed will always be the drive. There is no way around that because anything on your computer is always on a drive. However, you should think about a hierarchical file structure that will make it faster to find what you want. It sounds as though at present you have folders inside folders inside folders with no logical structure:
it takes a while to have to search through and click 10 folders before getting to my pictures all the time.
First of all, right-click any where on the panel and select 'Expand all'. All of the lists will be permanently expanded so you need to just scroll down the list without clicking on any folder other than the one you want.
currently its Folders>OSDisk(C>thenallthefolders
A structure that I and many others use is Drive>Photos>Year>Month>Day+descriptive text. Thus if I want photos from a trip to Italy two years ago, I look at the 2009 section of the list, May section of 2009, and click on "15, Rome".
Although most people stick with using a folder structure that enables easily finding what they want, some "gurus", including some members of the design team, claim that LR makes that method obsolete. They say that you could have all your image files in one huge folder or spread out randomly over half a dozen drives; as long as you diligently label them with descriptive keywords at import you can find them quickly using the database search function (filters). Thus in the example above I would in the left hand panel select the top item 'All Photographs' and in the filter bar select Text/Keywords and type in "Rome".
There is an even better method (IMHO) that combines the two methods. In the drop-down menu for Text on the filter bar the first item is "Any searchable field". This includes folder names. So even if I haven't assigned any keywords, if I type in a folder name (or part of one) I am taken to those photos. I type "Rome" and everything disappears from the screen except the Rome images.