The 50D does have micro adjust capability, it's a great camera, I gave mine away when I got my 7D and I miss it. Lenses can have the focus slightly off which will make the subject fuzzy. Mine was WAY off, so I sent it to cannon; they got it much closer to focusing correctly but it's still +7 off. With micro adjustment you can tell the camera to focus slight behind or infront of the object to compensate for slight front or back focus. Mine is now crazy sharp, I love the pics that it takes. It's my most consistent lens (other than the 70-200).
The post above warning to make sure you're doing everything else correctly before micro adjusting is great advice. The main thing with a long prime is shutter speed; keep it above 1/400 for still objects and over 1/800 (minimum) for moving subjects (ensure your using servo mode for moving subjects.