I've never actually used ETTL other than with the built-in popup flash. But I recently got a basic "Strobist" setup, and went through this learning curve myself. I found it to be pretty straightforward. To be fair, I did have the benefit of David Hobby's DVD lessons that I borrowed from a friend, and that helped. But it's really not that complicated. You have both the camera and the flash in full manual mode, and pretty quickly you understand how to set things to get the results you want. To me, it's really all about where you place the light(s) relative to your subject, and you'd really need to learn than even with ETTL because everything changes when you move the light.
And frankly, I think it is just more rewarding to learn it and set everything yourself rather than letting the camera do it automatically. i've come to feel that way more and more, even with non-flash camera automatic stuff. Shooting in manual more and more.
Finally, the cost difference is really significant. You can build a complete light stand setup with flash, radio trigger and modifier for about half the cost of a 580EXii alone. Around $200 per stand should do it if you use a non-ETTL flash. So to me the choice seems pretty clear, particularly for a studio situation.