If you guys want to see something really scary, try a test that will really push things.
BTW, John, good to see you here and I know I'm not posting anything new to you.
Anyway, set up a scene where you can get a "good" exposure in ISO 1600, pushed to the right a bit if you wish but with no blown highlights and no blocked shadows. Shoot the scene in Raw and in manual mode and with any in-camera settings for noise, exposure corrections and such turned off. So, what you get is the aperture and shutter speed letting in light, and the light is modified by the ISO amplification, period. The only thing of difference other than the ISO that we are concerned about is the noise collected by the sensor and then that collected "upstream".
So, we will change the one variable we can. We will keep the aperture and shutter at the same physical settings, so the same light is being collected, but we will lower the ISO (the internal amplification of the signal) to the "cleanest" ISO that Canon cameras "boast" of, ISO 100.
Now, this is 4 stops lower in Ev, "horribly unexposed", but the only difference in our settings is the ISO internal amplification! As to light, the exposure is the same!
So go ahead, you are in Manual, just lower the ISO to 100 and shoot away! After all, we all learned back in the film days that a low ISO is "less grainy" and using a high ISO "causes grain/noise", right?
And then bring your results into your Raw processor of choice. Now, it has been said that some Raw processors don't handle such things as well as others, I don't know where the lines are drawn. Raw processors use their own internal processes to handle things.
But, the idea is you now have to boost your ISO 100 shot by 4 stops to be the "equivalent" of the ISO 1600 shot. You can do this in a straightforward way with the ACR/Lightroom Raw processor. In DPP you will need to set the Raw tab to Linear processing and then boost the Brightness to the max of +2 Ev and then go to the RGB tab and boost the brightness until the levels match the ISO 1600 shot.
And now you can compare "real" ISO with the "real" native 1600 ISO.
You may be surprised! There has been a lot of analysis/evaluation that points to the fact that the lower Canon ISOs are more noisy than the higher "native" ISOs! This does tend to level out at ISO 1600, maybe more in newer bodies, but the point is that there is value added from using a native higher ISO as a "starting point", and it's better if you can ETTR more by bumping the aperture/shutter speed/Exposure Compensation a bit, as long as you don't blow highlights!
Well, I'm tossing it out -- play in the sandbox and have fun!