I'm at my wit's end. For no reason that I can fathom I'm suddenly overwhelmed with printing issues. I've been outputting excellent prints on my Epson 3880 for over a year, using a custom profile created with ColorMunki, out of PS CS5 and LR3. Suddenly prints came out with a light cyan block outside of the image area.
I (we) narrowed it down to an issue with the custom icc profile, as I could print the same image fine as a pdf or out of Preview. I also could print ok with the canned Epson profile.
Created a new paper profile, no cyan block, but from now on the image looks double-profiled. Not at all accurate, but could still print ok with the Epson profile. Then things really turned to ****.
I've uninstalled and installed the latest Epson driver, uninstalled and reinstalled ColorMunki and created new profiles, and now uninstalled and reinstalled PS. Now my print dialog will not even let me choose the Print (e.g. b&w) or Color Mode.
I couldn't print a b & w with the excellent Epson controls if I wanted to.
To add to the frustration, I have an near identical system at work (same OS, printer, softwares) and I have no issues, custom icc is fine, print dialog displays all options properly. only diff between the tow is it's an older Macpro, with a different card.
I'm on a new Macpro, but I've been breezing along for months with no problems. Epson, Adobe, X-Rite support has been virtually useless, they all say there's no problem with their product, it's someone else's issue-- yeah, mine!
Does anyone have a clue, because at this point, I sure don't... (calling René...)
I just want my digital visual life back...
To clarify, I've deleted the custom profile and uninstalled ColorMunki, and am running Snow Leopard 10.6.8
More: Printer dialog presents correct options in LR and Preview. Guess that means the issue is in Photoshop. But there are never any issues in PS (at least whenever I talk to Adobe support...)

