I backpack and occasionally hitch, and always have a DSLR with me. Not ever in an official photo bag - I have a padded insert from a crumplier I either put in my main pack or in my daypack. One cam, one lens easily accessible, and a compact for places I don't want to take the big gun out.
Backpacked (but didn't Hitch) through Argentina no probs with 2 5DIIs, a 100-400, 24-104 and pair of Zeiss primes. Well, no problems except for the weight. I am fully insured for theft or accidental damage, however - rather give up the gear than my life. I can always buy another camera. Just make sure the memory cards are somewhere people aren't likely to steal 