There are definitely tricks and procedures you can use to minimize ghosting and articfacts along the edges of moving things, but I have yet to find a solution which always resolves all issues. Depending on the proximity of the moving object, the amount it's moving between shots, the difference in light/color between the object and the background will all play into the degree of problems. When you have a difficult scene with these circumstances the only way (I've found to date) to resolve the problem is with cloning.
One thing which makes a big difference to the amount of blending proficiency needed is what you're going to do with the photo. Many times I'm able to get away without cloning for a shot which is going to get posted online, but if I'm going to be printing the shot large it's another story.
If anyone has a way to fix these types of blending issues without resorting to cloning, I would be very interested in hearing them.