So like an idiot I went to do a shoot indoors with my 1dMkIII for the first time and for some reason I can't fire my 580EXii remotely with my Pocket Wizards and my camera set to "M" mode. It fires with the camera in AV mode. The sun kept going in and out through a window and it kept changing my lighting all the time.
I NEVER had this problem with my 50D.
Could there be something set on the camera that is preventing firing in M mode ?
Yes I know, I should have tried this BEFORE I went to shoot 
Can anyone help ?

