
Canon 5d3 using a 622c on camera and a 622c on a 580 EX II off camera. Could the 580EXII then act as a commander to control other flashes through TTL optically, and would those other flashes be able to be set up via on camera menus if compatible with canon TTL?
No. There is only one Master - the on-camera 622.
There is a trick (Syl Arena calls it "Free Agent Wireless" that can be used, but the 580EXII must be in Master and Manual modes (No ETTL). There can also be a significant "propagation delay" as the remote Master starts to set up any slaves only after the Fire! signal has been given by the camera.
Of course, Mix mode should accommodate any special configurations. You simply need to buy a sufficient number of YN-622s.