Depends on your usage. If you're going to be at the long end of the zoom, then the 300/1.4x would be better. I made this exact switch. The 150-500 is basically an f/8 lens... for best results, whereas you can have 420/5.6 with the prime. IS is much better on the Sigma, but acceptable on the 300 combo. I can take static shots at 420mm down to ~1/125(on crop)...which is just a little better than 2 stops.
The 300 combo, is far and away.. a better handling setup. The Sigma is big/long/heavy, and i was very unimpressed with the zoom creep.
If you have a 1D series body, you can use a 2x on the prime.. for 600/8(though not the best IQ) and still retain AF..albeit slower, but you're at the limit with the Sigma @500. A 1.4x on the Sig, would put you to 700@f/9 and MF. While i found the Sigma ok at 700(i've tried 1000/13 and 1400/18 as well..more for fun
), you start to need a lot of light, and MFing that lens isn't as easy as the 300.. for sure.