I have first hand experience on a couple of these points:
1) i fly through FRA a few times a year, if you are on lufthansa you can (generally) get away with the US standard of a carry-on and a small bag, so if you want to split the camera gear and computer that could be an option. Even when coming back on LH i have not gotten problems (but the small local european airlines like Vueling, they will catch you on that second bag....)
2) i've been using a shapeshifter for nearly 2 years now, both with camera gear and without (i think it makes a great work backpack, pockets keep everything organized), so i really like the bag. But a few things. Based on your gear list i think you could fit all that but it will be heavy. The SS is an 'ok' backpack for walking when loaded, it's not like the f-stops which are better suited for walking long distances, but it will work in a pinch. if you need a little more capacity you can also get a speedbelt and use the waistpack attachments.
But i'd repeat what others say and think about the giant laptop and the big lens, that's a lot of weight and the SS will not carry that much weight comfortably. Remember that FRA is a really big airport, i've had 30+ minute walks before carrying a pack and a carry-on. it's not fun. and remember that all of your accessories (ipad, phone, power-adaptors, batteries, bottle of water) will only add to the weight!
another option is a pack more suited for carry like a Kiboko, the only concession there is that those packs don't make good walk-around packs (IMHO), the SS actually makes a good walk-around pack at your destination as well, especially with the shoulder clips so you can wear the camera ready for shooting.