Interesting, I do a lot of in-camera custom white balancing but always tried to fill the frame with the gray card. Never heard that you don't have to do that, just the center section is enough.
So I tested on a Canon 5D3, and sure enough, just filling a small center section gives the same results as filling the entire frame. Tested under tungsten 2700k and natural 6700k light. Placed the gray card on a bright red shirt, so everything outside the center section shot was red and would throw the WB off if that outside area was used.
No problem using a small center section only. In camera WB matched custom WB in ACR exactly on temp and only 1 or 2 points difference in tint. Good to know.
Also, even though shooting raw I like to set in-camera WB because doing so makes the in-camera (jpeg) histogram a much closer match to the true raw.