Well, depends on your budget really, but if you can get the IS version.
Why?! IS helps in panning, and auto focusing.
Panning:
In "Mode 2" the IS stabilizes only in one direction. in this case it aids in shooting images, that have the background blurred directionally.
Like in this picture:
http://farm5.static.flickr.com …4303090225_d9a9b02987.jpg
it also helps with AF, imagine, the camera in AI SERVo mode seeks moving targets, and between a burst, it focuses. On newer cameras this is 6 frames per second, that means the camera has less then a tenth of a second time to re-focus after a shot, for the next one.
If you hand-hold a 400mm lens, there is also shake, if you use IS, its much easier for the camera to focus spot-on.