For focal lengths shorter than the register distance, the lens requires a "retrofocus" design, which is why most of the wide angle lenses in use on DSLR's are bigger than the equivalent focal length lenses on rangefinders. The need to add the motor and other components for both the auto focus and electronic aperture are also more bulky again adding size and weight to the lens. Once you move much past the register distance though you start to have to use a telephoto design, which again adds complexity to the lens. For long fast lenses such as say a 300mm f2.8 the difference in size would actually be minimal, as the size of the lens will be limited as much by the size of the glass elements by the other factors. It is interesting to note that there are very few lenses above 135mm focal length avilable of rangefinder cameras.
Alan