I have the Vertex 300 AW and have been using it for about 6 months. It is a very large bag, but very comfortable to carry.
This pack carries everything in my sig line except the 10d and the 120-300 2.8. It also carries a Hoodman loupe, 1.4 extender, cables and cords, bulb blower, (2) LP-E6 battery chargers, filter system, extra CF cards cleaning supplies, and the pack is not overfull. All together it weighs about 32 pounds full.
I carry an Induro AT313 tripod (28" long),on the rear of the pack when hiking. The shoulder pads have plenty of padded length, unlike my older large Tenba pack, which always cut into me a little. As far as fit, it's very good and I'm 5'11" with a long torso. The waist belt sits a little high on me because of this, but doesn't make it uncomfortable. In fact, most of the time I don't even use the waistbelt on short hikes.
The pack has a weather resistant main zipper, and a rain cover that stows in the bottom, along with a zipping cover to cover the shoulder straps, when carrying the bag instead of wearing it.
http://store.lowepro.com/backpacks/vertex-300-aw

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