I have owned the 100-400L for several years, and have no issues with dust in the lens. This lens does not suffer from dust any more than any other zoom lens that extends when changing focal length.
As for the 100-400L vs the 70-300L, the 70-300 is a newer lens with newer optics and a better image stabilization system. It is a better lens than the 100-400L in every way, except for one critical area -- focal length. If you need the reach, the 100-400L will perform much better than the 70-300L with a teleconvertor attached. As others have recommended in this thread, select the lens that meets your focal length needs without attaching a TC.
Some people do not like the push/pull zoom mechanism of the 100-400L, but I find it very easy to use, and much simpler and quicker than a twist zoom once you get used to it (which only took me minutes).
I wouldn't trade my 100-400L for a 70-300L, as I need the added focal length. This is my primary wildlife lens, and reach is critical. While it's a little bigger and heavier, the 100-400L is still quite compact for the reach and versatility it provides.


