The answer is... It depends. Start with Profile when there is one.
Always do the Capture Sharpening AFTER NN.
See my own 2-page, abbreviated, getting most from NN thingy:
http://postit.rutgers.edu …injaWorkflow%5FJack%2Epdf
The answer, IMO, depends on
1) particular camera body;
2) ISO speed selected;
3) nature of image (large patches of similar color and tone or not);
4) if camera ambient temperature is hot during shooting;
5) whether you are using NN on in-camera JPG image (suck with noise and artifacts) vs. 16-bit TIFs from RAW files (always fewer artifacts);
6) if images were underexposed under adverse light and "pushed" on RAW conversion or in PhotoShop.
I found for 20D, and high ISO champ 1-D MkII; Shooting ISO 800-1250-1600; with good RAW exposures (that's the caveat);
that converted 16-bit TIF exposures are extraordinary. I start with NN downloaded profiles, BUT ALWAYS ADJUST DOWNWARD USING THE DIRECTIONS IN MY GIDE ABOVE the Filter tab default effects for Luminance and Color, which are set at 10-10-10. For Luminance e.g., I usually end up with 7-4-10 and for Chroma noise 3-3-10.
Wow. Way reduced! Then I save this profile under a new name, use it in batch mode, and/or recall it in future.
So, I have modified profiles named, like "1DMkII ISO-1250 TaeKwonDo.nzp", etc.
It's different on Scans, and on Nikon digital images, which are far noiser, even at ISO 400.
Hope that helps.
Jack