I recently had a chance to give Piccure+ a good look over.
Using it as a plugin, it offers sharpening for lens softness that works rather well on my (already good) wide lenses such as the EF11-24 and TS-E17 (used with shift)
It's not going to be something for my day to day work flow, at over 6 minutes for a 1Ds3 file, but for large individual prints it's something that is likely to affect my whole workflow from RAW conversion to print. For example, to get best results you probably need to turn off any sharpening in your RAW converter
The software has a few glitches, and from my POV really needs to be used on a duplicated layer (to fine tune and mask) but has a distinctly different feel to many other sharpening tools I've tried.
It also does shake reduction - like many solutions it works well sometimes