I downloaded the raw files. Just to make sure we are comparing apples to apples, I verified the EXIF. Both shots are made using the same lens, aperture, lighting, shutter speed and such. My copy of LR can't open the 5DSr file, which is a good thing. That forced me to work in DPP 4, which doesn't apply any default edits.
The first thing I noticed is that the 100% view of the 5DSr file is a lot narrower view. The second thing is that it is a lot noisier. Looking at the 5D3 at 100% and the 5DSr at 50% yields a better size comparison. Even when looking at the the 5DSr shot at only 50%, the 100% 5D3 view is clearly cleaner. I am not intimately familiar with either of these bodies. From experience with my 6D, I'd guess that the noise difference between the 5D3 and 5DSr is more than one stop, and less than two.
My conclusion is as I expected. The much larger pixels of the 5D3 yield cleaner results. The 5DSr yields high-ISO results in line with its pixel density, and fares no better than any other high pixel density camera, such as the 7D2. I am not sure what the point of 50MP is. It certainly is not high-ISO noise performance.
The 5D3 is on the left. 5DSr is on the right. This screen shot does not do the difference justice. It is glaringly obvious on a 22" monitor. I realize the size difference matters. Making the 5DSr shot larger is only going to accentuate the noise.

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