I use the 600 RT and I shoot with the camera in manual, underexposing the background by 2/3 of a stop, the flash in ETTL and set the ISO at 100 or 200. My shots come out perfect every time.
I do that outdoors as well. About one stop. Indoors as close to metered centre as possible as I can and try not to let it go lower than 3 stops. 2 is better.

