Frodge, I think the question you are asking is, "When stopping down, at what aperture do I begin to lose image quality?"
There are really two answers to that question. One is lens related, the other sensor related.
Lens first. There is some aperture, specific to each lens, where you will get the highest possible resolution and contrast. Both of these, taken together, produce what is called by most of us, sharpness. This is specific to each lens, and is what MTF charts attempt to show graphically. Generally, but not always, that point comes when you are stopped down 1 or 2 stops from wide open. Most lenses have a range of about 3 stops where they perform best. Fast L-primes like the 135 f/2L are at their best stopped down an bit. It is excellent (PZ.de's rating) from f/2.8 through f/8. Slow consumer zooms like the efs 10-18mm STM are at their best near wide open. (You can see all of this graphically depicted in lens reviews at photozone.de.) Not because they are really good, but because efs lenses mounted on apsc cameras run into the other aspect of aperture affecting image quality: the sensor.
The sensor. Each sensor has a specific size to its individual light buckets. Apsc sensors crammed with 20 MP have relatively smaller sensors. A full frame sensor with the same 20 MP will have larger light buckets. A full frame sensor with only 12 MP will have comparatively huge light buckets. The size of the light bucket matters because of the lens. As light passes through the lens, it does a lot of bending and bouncing: it gets diffracted, or spread out. Stopping down and forcing the light through a smaller hole makes for more bending and bouncing. When the light from a particular point spreads out too much, it spills over the edge of its particular light bucket. For each specific sensor, the aperture that causes this to degrade your image is known as the diffraction limited aperture, or DLA.
Michael at TDP (http://www.the-digital-picture.com …D-DSLR-Camera-Review.aspx
) usually includes DLA data in his camera reviews. Go to the site just quoted and look at the DLA table. The DLA of the 60D is f/6.9. Beyond that, you begin to lose IQ due to the sensor. The 135L on full frame is excellent at f/8. If it were tested on a 60D, f/8 would be detrimentally affected by DLA. Compare the 5Dc to the 5D Mk III. DLA's are f/13.2 & f/10.1, primarily because the Mk III has more MP, which translates into smaller light buckets, which means DLA sets in at a lower aperture.
I don't have the best eyes, but I have LR and a 22" monitor. I can't see any negative effects of DLA until well past what TDP lists as DLA. It is my opinion that you can go about 2 stops past what he lists. Diffraction may be there, but it is not visible or detrimental to IQ. I have never had a problem using my crop cameras at f/11-16. I tend to use my 6D with fast primes wide open, so I will never run into DLA. I use UWA lenses (<20mm) a lot on full frame. At 15mm I get all the DOF I need at f/5.6-f/8, so again, I'll never run into DLA on my full frame.