Admittedly I have not made focus stacking a regular practice. However, the coming addition of a Cam Ranger inspired some practice work. So I bought the wife a bunch of flowers (brownie points) and then pointed the camera at them. Out of 12 stacked images (which consisted of 129 total captures) Photoshop CC was able to render 3 quite well while butchering the other 9. The 3 images Photoshop handled well were the ones with the least amount of focus stacking: anywhere up to 5 images. It also struggled with any sets I used a focus rail for. It seemed the alignment of the images was Photoshop's achilles heal in my tests.
After researching stacking softwares Zerene's name came up over and over and over again. With a 30 day trial and coffee in hand I have had it crunching away on the failed 9 stacks Photoshop couldn't handle for the past hour. So far, it has almost "nailed" 7 of the 9 failed stacks and left the other 2 in a state where they're easily fixable. On top of that it took me 1 hour-ish to do all the same work that took me close to 3 hours yesterday.
Yes, I realize Zerene is made for this niche and should function this well for focus stacking. I'm not knocking Photoshop because it can definitely handle things the same way, but it needs a lot of hand-holding to get there. My point is that I'm impressed with Zerene for this task and am adding the Pro version to my post processing arsenal.
Below are examples without any post processing work except alignment and stacking (PMax in Zerene's case).
Yellow flower #1 is from Photoshop
Yellow flower #2 is from Zerene
This is a 7 image stack where Photoshop struggled with the background borders and left a blurry spot on the bottom/middle of the flower. It definitely did a better job at handling artifacts around the peddles over Zerene. But those are easily fixed in Zerene.
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Good to see that someone can use PS stacking effectively. I tried the stack below in PS and then in Zerene. PS was an big fail (and I'm using the latest update) while Zerene did great. It just needed a minor touch where the background water meets the profile of the foreground rocks:

