Setting up X100T JPGs for 4x6 Printing

I'm trying to get my JPG settings dialled in for 4x6 prints. I think I have it mostly sorted out (-2 NR; +1 sharpening), but I'm not sure what size JPG I should be shooting. I don't want to have to resize JPGs before I submit them electronically for 4x6 printing.

Should I use the "small" setting for the JPGs? "Small" is 2496 x 1664, so it is still larger than what I normally submit JPGs at (1800x1200). I'm a bit worried about detail loss as a result of the data that is "tossed out" due to resizing by the printer. I don't know if it will be marginal or significant. If it will be significant, should I just use "Large" (4896 x 3264) JPGs and resize them before I sent them off to be printed?

Either shoot medium or large and no need to resize them as the resolution of the camera or JPEG won't define the print size. Your X100t shoots a ratio of 3:2 so if you print at 6 inch by 4 inch your print wont be cropped.

Simply shoot in large and upload