It is wise to consider your own specific needs. If you have a lot of important low light situations, bigger sensors would be better.
I have a friend who has a compact super zoom camera and it takes terrific pictures, because he is practically always shooting in good light. He has noticed a reduction of IQ in low light, but those situations are rare for him and the tradeoff is acceptable.
Rebels are a compromise, as all cameras are. I have an SL1 Rebel to back up my 7D2. The IQ of the SL1 is terrific, and I don't notice any need to do MFA on the SL1 - EXCEPT for the 100-400 II with 1.4x extender. That combo would be unusable on the SL1. And the frame rate is a lot lower. And the SL1 only selects whole f stops, like f/11 and f/16 - no f/13. Sometimes that matters. Again, it all comes down to your requirements.
Yes specific needs is all about what you grab in your toolbox.
I just cannot accept that you cannot MA a Rebel. That's to purpose of the price point between a rebel or xxD crop.
As a new adopter of the fuji system I'm finding the 16mpx fuji body and Kit lens produces nicer colours and more micro contrast than a 24-70L mk1 or 24-105L. The 18-55 kit lens is mind boggling for a variable aperture 2.8-4.0 zoom with image stabilization. No micro adjust needed and small light form factor.
If I owned a 6D I'd supplement it with a sony A6300 (lens not cheap) or a Fuji. Last in line would be the Micro 4/3 system. I own a M43 system so I can easily comment that a Sony a6000/6300 or Fuji is more up my alley in IQ and lower light performance.

I had a 60D for about 4 years. My go to lens was a 15-85. I also had a 28 1.8, 35 IS, 50 (various), 85 1.8, and 135L. I shot them wide open, frequently. I never felt the need for MFA. I am quite sure I'm not the only one. Of course, MFA would have come in handy if I'd had a problem. I didn't.

