Heya,
I will echo Tom's sentiments.
The more you dedicate to wildlife in general, you will develop techniques and use the environment and often be so close that some longer focal lengths become too long. I have done this myself, where I proclaimed that "there's never enough reach when it comes to wildlife!" and so I bought a 600mm. 600mm really is nice to have, you get tons of reach, especially paired with an APS-C sensor. But, after I calmed down about finally having reach, I realized I had to actually go away from wildlife/birds to be able to actually use it at 600mm in a lot of situations because I was getting closer to them the more I learned. What I really figured out was that the 600mm is really handy if you're shooting very small wildlife/birds at close distance, but actually is too long on large wildlife/birds at closer distances unless you're into detail shots of an eyeball or something, and not concerned with composition. I definitely have found that getting closer to the wildlife/birds, and having enough environmental context to also have room to crop to make a nice composition is more important than just framing up an animal/bird and snapping a shot. Kind of the difference between a photograph and journalism perhaps. Or something like that.
So these days, my 600mm actually sits on the shelf more and more, and I actually use my 300mm the most now. I use a 300 F4L IS with an APS-C & full frame (to control field of view).
The environment dictates nearly everything. As Tom pointed out, if you're really far away and trying to frame up a large mammal at 600mm on APS-C, you have to actually be very far away and when you're in the environment like the Smokeys, that means trees, brush, etc, and potentially dew point water vapor hanging around depending on temp and time of day to shoot through; not really a good thing as you end up with a lot of "kinda see them" type shots, where they're constantly concealed by something.
If you're just walking around on typical high traffic trails, a long lens seems like a good idea.
But if you're scouting, using a blind, or a tour service, or hiking in deeper, etc, you'll end up closer and likely not need the longer lenses as much as you might think.
Consider a 70-300L IS. You end up with the same thing, without the TC, and could probably trade it straight up.
With a good stable mount system, you can get really low, steady, and handle even really low light no problem.
+++++
Your gallery has a 70D + 100-400L image, did you rent or sell or something that 100-400?
Very best,