In my earlier forties size was irrelevant. I would mule all day two DLSR rigs on me with two big zooms attached. Coming closer to fifty I started to dislike it, because I have to be close to small child and bumping full sized camera rig to children heads is not pleasing experience.
Right before turning fifty I sold my recently updated FF DSLR, sold 50L lens, gave to our first daughter fast zoom with Canon TTL flash (she takes pictures for money with 5D MKII and flash) and kept old and trusty 500D with 24mm pancake on it.
I quit from taking FF DSLR outdoors few years ago. Too large for dog leash in one hand and kid hand in another hand. Later FF DSLR rig became silly to even kept it at home for daily photography. It was so bulky and taking space. I would take it to party... wearing it was nothing but inconvenience and finding place to leave it somewhere was problematic.
And FF DSLR with fast zoom became heavy to me at the age of fifty. Now even holding it for fifteen minutes is not pleasing at all.
Also, I quit from FF DSLR and large zoom on it (17-40 L) long time ago for street photography. Switched to 500D with Olympus.Zuiko MF pancake. It was fun until I realized what I like it in BW and what film is better for BW street photography to me. My first street film camera was Olympus XA, smallest RF camera made. It was major breakthrough for me in the street photography, small photo camera and bw film. I became more creative.
Later on I switched to normal sized Bessa R and after year or so as many others I became to conclusion what best ergonomics, size and weight are on Leica side.
Just like it is expanded in the comment right above. Leica has all controls and Leica lenses have controls which allows fingers to fiddle for hours and without fatigue.
Here is my current RF herd:
Any camera on this picture has weight which is close to Canon 6D weight. But prime lenses are smaller and 135 or digital rangefinder camera body has ergonomics and shape which is working best for me. With DSLR on me it is kind of bouncy, with RF it is somehow on me.
For travel photography for sometime now I'm using only one camera, it is on the left and only one lens (it is on the camera). Leica Canada M4-2 and Leica Germany Summarit-M 35 2.5.
It feels compact, I could wear it all day. No worries about battery charging overnight. And I'm getting prints I want from it. If I need digital snapshot, the Iphone is now sufficient most of the time.
If I want better digital pictures for travel, I have Panasonic Lumix P&S with great Leica zoom lens on it.
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In 2016 I went on trip where I was very limited with carry-on space. And M4-2 with little Lumix and iPhone where sufficient. Ten rolls of film are not taking much space, either.
The only serious limitations I have in IQ with this small P&S and digital Leica cameras is for low light. These days I prefer f5.6 and f8 to have everyone in focus and with these apertures it is often not enough light. So, I using very small and light Leica TTL flash. Or 500D build-in flash. I almost purchased high ISO king 6D earlier this year, but went for low ISO only M8 instead. Because 6D and pancake on it is still too bulky for me to use it without inconvenience. I don't mind to wait for Canon to make FF DLSR which will be similar to their Rebels body. I would prefer it to be similar to 135 format Rebel 300 which we still have at home. Small, light and nice SLR.
Unfortunately tiny and cute mirrorless gizmos with TV screen instead of normal optical viewfinder is not my cap of tea. I don't mind iPhone and classic digital P&S, it is fun, but for more serious photography I still trust my eye and optical viewfinder.