This is one of those questions where I think it is important to recognise that theory and practice can be very different. It might well be that 'theoretically', lenses with IS are compromised in some way that affects sharpness, simply on the basis of physics.
But for me, what counts more is real-world 'practical' outcomes. In this case, it seems that any difference in sharpness is too small to be material and, in any case, the benefits of IS in terms of reducing camera motion blur more than compensate in terms of 'apparent sharpness'.
So, theoretically - Yes.
Practically - No. Perhaps even the opposite, because IS helps to produce a sharper image by reducing camera motion blur.
5D3, 7D2, EF 16-35 f/2.8L, EF 24-70 f/2.8L II, EF 24-105 f/4L, EF 70-200 f/2.8L II, EF 100-400 f/4.5-5.6L II, EF 1.4x III, Sigma 150mm macro, Lumix LX100 plus a cupboard full of bags, tripods, flashes & stuff.