I keep my 1DXs and piles of lenses for when I need less resolution and "more performance". My primary cameras are all 50-150mp Hasselblad and Phase One. I don't use these for the resolution, pixel count, or cropability - but rather for dynamic range and fine detail performance. It also allows me to shoot for the original intention, which may be catalog/print/web, but allows me to later sell/use the same file for poster/signage/wallpaper printing. The smallest print I make is 11x14 as my "wallet size" with 16x20 being standard, and that's for personal/vacation work. There's been many-a-time where a client called back a few months after the original job asking if there was any way I could re-shoot the image for signage or billboard. Since I already have the shot ready, it saves them time and money and makes me extra with little work. This has also come in handy for revisiting my personal work where originally a shot looked ok for smaller printing, but later technology advances (and time) allow for additional processing to create an image that looks good enough for large printing.
I never considered the 5Ds/R due to the small sensor size, tiny pixels, and low(er) dynamic range. The R5/6, Sony, and other mirrorless cameras are not an option for me either due to no OVF, poor tetherability, weak operation in low light (finder-wise, not image), and smaller pixel sizes. The smaller bodies are also a nightmare for me to handle. If it says anything, my "vacation" camera is usually an older H body and back. I don't mind the weight and don't really find the bulk that people tend to complain about.
The biggest issue with higher pixel counts isn't that mistakes appear easier, but rather than the camera is more sensitive to poor technique, lighting, and stability. However, a larger sensor (with larger pixel size) gets around that quite a bit.
The computer side is a poor excuse for not using modern gear and decent resolutions...large drives are cheap, RAM is cheap, and if a shot is captured well ("get the most in the can"), there is actually very little editing needed to prepare the shot for output.
Also, I've printed stuff off the X at 20x24 without any noticeable issues. Well, at least until you put one of the 50mp images next to it. You then can see where it falls apart. But to a client or end user who doesn't see that 50mp, they'd never notice the difference if the lower res image was processed and printed well.
A colleage of mine has the 5DsR and we shot it in studio next to the MF using a studio shot where there wasn't any noticable DOF falloff (to eliminate the optical falloff "wow" of MF) - the tabletop shot was completely sharp with a neutral gray background. It consisted of polished rocks, gems, and metals on a bed of black and white silk and cashmere. It was very easy to tell which one the 5DsR was by the weaker fine detail and poor(er) rendering of colors/textures in black and white fabrics, less "sparkles" in the speculars, and duller color transitions in gradients. Both were printed to 20x24 for this test.
Even when not printing, the higher pixel counts are sometimes noticable, but not as much as with the larger sensors; that's where the tonality and colors are much better with higher MP and sensor size.