Yes, you certainly can. I find manual shutter and aperture and let the iso land where it needs to on my R5 is fantastic.
I might be a little more ISO control freak on the R7 though. But in either case, it's great to make all the decisions based on shutter and aperture.
That is what I do I usually shoot C1 C2 or C3 where I have various manual shutter and aperture's set and auto ISO and usually set to EV/EC to 0 or -2/3 and then when a bird is against the sky try to change to +1 or +2 on the exposure comp




