I'm with CDS - the 28-300mm is really a specialist lens, for tasks such as fast moving photojournalism. It's for when you need wide angle to fairly long telephoto in a single lens on a single body, but the result is a "jack of all trades, master of none" lens.
It's a slow lens - f/4 by 50mm is extremely slow, it's heavy (noticeably heavier than the EF 70-200mm f/2.8L IS, which is a lens I own), the hood has to be very small because of the 28mm end and it's optical performance is mediocre, especially at both extremes. I found it very clumsy to use when I tried handling one, though I am familar with rotary zoom lenses and not push-pull (I own three rotary zoom L lenses - EF 16-35mm f/2.8L, EF 24-70mm f/2.8L, EF 70-200mm f/2.8L IS).
For situations when no other lens will do, it's great - but if you have the option of splitting the range into two or three, do so. Most people would be better splitting the range with something like EF 24-70mm f/2.8L and EF 70-200mm f/2.8L IS, which are much faster lenses, too.
As CDS says, Canon sell some prime lenses that should work very well for portraiture and not break the bank - such as the EF 50mm f/1.4 and the EF 85mm f/1.8. I'd sell the 28-300mm and buy more suitable lenses if portraiture really is your main application for the lens.
David