The Tamron 200-500 does not have full time manual override, so you can't just correct focus manually if AF picks up on a twig in front of the subject. Once you get used to using full time manual override you will never buy a lens without it.
I would choose between the Sigma 50-500 and Canon 100-400, both of which have manual focus override. I took test shots with both lenses before making my decision and image quality is about the same. On some shots the Sigma looked a little sharper than the Canon, but not so much that it would make me choose the Sigma over the Canon.
The Sigma has the variety of a better focal length range. Both the 50mm and 500mm ends of the range are good. It also zooms by twisting a ring, which I prefer to the trombone action of the Canon.
The Canon 100-400 has image stabilization, which is a real advantage if you do much hand-held shooting. Also, it uses 77 mm filters, which are cheaper than the 86 mm filters for the Sigma and are interchangeable with filters for other common lenses such as the 70-200/2.8, 24-70, 17-40 and 16-35.
I would make my choice between the 50-500 and 100-400 and would base it on shooting style. If you use a tripod or other support most of the time the 50-500 gives you more range of focal lengths. If you do much hand held photography, the IS is a useful feature.
I chose the 50-500 because I use a tripod or window pod most of the time. On my trip to South Africa I used a private vehicle, so I could mount my lens/camera on a window pod most of the time. I used the 500 end of the zoom range very often, especially for birds and small animals. (I use a 20D. Your 5D will be even more limited for telephoto use.) The only time I wished I had taken the 100-400 was on an early morning game drive when we had to go in the guide's truck and shoot hand held. I managed to get some good shots with the 50-500, but would have had a higher percentage of keepers if I had image stabilization.
Someone mentioned the 300/4. I took a 400/5.6 on a previous trip and missed some great shots when game appeared too close to the vehicle and then moved off while I was trying to change lenses. It will give sharper pictures, but not that much sharper and a missed picture is not as good. If you do go that route, be sure to also take a 1.4x teleconverter. I found that I wanted all the focal length I could get, even with a 500 mm lens on a 1.6x crop camera.
Whatever lens you choose, have a good trip. With any luck you will come back with some great photos. Don't let the guides rush you so much trying to see the BIG 4 that you miss out on opportunities to spend more time waiting for good compositions or photographing other interesting subjects such as colourful birds and tiny antelope. I found that the main hinderence to getting good photos was other people who just want to see something and then move on to something else. My best photos came when I could wait and watch for a more interesting action or composition to develop.
descisions eh. I have contact Kerso to find out about availablity, we will see.



